Kadar IL-10 Mencit Balb/C Terinfeksi Plasmodium berghei dengan Pemberian Fraksi Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer (The IL-10 level of Plasmodium berghei-infected Balb/C Mice after Methanolic Fraction of Bangle (Zingib

Authors

  • Asis Fitriana Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember
  • Bagus Hermansyah Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember
  • Muhammad Afiful Jauhani Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember
  • Wiwien Sugih Utami Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Jember

DOI:

https://doi.org/10.19184/pk.v6i1.6791

Abstract

 

Malaria is an infectious disease caused by Plasmodium spp. The cause of mortality in malaria is the parasite’s resistance to malaria drugs and immune system problem. Interleukin-10 is an anti-inflammatory cytokine during plasmodium infection. Bangle is a herbal remedy that contains high amount of curcumin showing immunostimulant activity. The purpose of this study was to determine the difference of IL-10 level in Plasmodium berghei-infected Balb/C mice given with methanolic fraction of bangle (Zingiber cassumunar Roxb.) as a complementary therapy. This study was a true experimental with posttest control group design using 25 mice Balb/c which divided into 5 groups (A, B, C, D and E). All groups except group A were infected with P. berghei. After positively infected, group B was not treated, C was treated with artemisinin, group D was given with artemisinin and methanolic fraction bangle 0,017 mg/gBW, group E was treated with methanolic fraction bangle 0,017 mg/gBW. The result showed that group D had the highest-level of IL-10 among the treatment groups. The Post Hoc LSD test showed p value ≥ 0,05. In conclusion, there was no significant difference of IL-10 serum level in P. berghei-infected Balb/C mice given with methanolic fraction of bangle (Z. cassumunar Roxb.) as complementary therapy.

Keywords: Interleukin-10, Plasmodium berghei, Bangle (Zingiber cassumunar Roxb.)

 

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Published

2018-01-17

Issue

Vol. 6 No. 1 (2018)

Section

Articles

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