Sintesis 1-(4-metoksibenzoiloksimetil)-5-fluorourasil sebagai Agen Antikanker

Authors

  • . Ifada Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Ayik Rosita Puspaningtyas1 Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Ika Oktavianawati Jurusan Kimia, Fakultas MIPA, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Yuni Retnaningtyas Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.
  • Nia Kristiningrum Jurusan Farmasi, Fakultas Farmasi, Universitas Jember Jl. Kalimantan 37 Kampus Tegal Boto, 68121 Jember.

Abstract

A new compound from 5-fluorouracil (5-FU) derivatives, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil has been synthesized in a two steps reaction, alkylation (5-FU and formaldehyde to form 1-hydroxymethyl-5-fluorouracil) and esterification (1-hydroxymethyl-5-fluorouracil and 4-methoxybenzoylchloride to form 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil). Reaction product purified by chromatography column, the product has been characteryzed for physical apperance is a yellowish white, crystal and melting range 168-169OC. Based on the FTIR and 1H-NMR spectra, it showed that the purified product does not contain a single compound. This fact is supported by Thin Layer Chromatography (TLC) result showing two spots for the pressure of 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil and 4-methoxybenzoate acid.

Keywords: 5-fluorouracil derivates, anticancer, 1-(4-methoxybenzoyloxymethyl)-5-fluorouracil, benzoylation.

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Issue

Vol. 1 No. 1 (2013)

Section

Articles

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