Analisis In Vivo Aktivitas Antihipertensi dari Protein Biji Melinjo (Gnetum gnemon) Terhidrolisis

Authors

  • Yeni Tri Puspitaningrum Fakultas Kedokteran, Universitas Jember
  • Erfan Efendi Fakultas Kedokteran, Universitas Jember
  • Tri Agus Siswoyo DAST (Center for Development of Advanced Sciences and Technology), Universitas Jember

Abstract

Hypertension is a serious health problem and requires a good handling. An alternative treatment for hypertension is required due to the treatment of hypertension took a long period of time causing unwanted side effects. Melinjo seed hydrolyzed-proteins have an ACE-inhibitor activity, an antihypertensive effect. This study aimed to determine the antihypertensive effects of melinjo seed hydrolyzed-proteins in hypertensive rats. Wistar rats induced with prednisone 1,5 mg/kg body weight and 2% NaCl for 7 days and then treated. There were 7 groups: a normal group K, a group K(-) which is a hypertensive rats without treatment, a group K(+) which is hypertensive rats with captopril 2,5 mg/kg body weight on day 8th, and four treatment groups P1, P2, P3, and P4 which are hypertensive rats with melinjo seed hydrolyzed-proteins with a dose of 5, 10, 20, and 30 mg/kg body weight on day 8th, respectively. Blood pressure was measured before and after treatment every 1 hour for 5 hours. The results showed that melinjo seed (Gnetum gnemon) hydrolyzed-proteins can decrease blood pressure in hypertensive rats.

 

Keywords: Antihypertensive, Gnetum gnemon, Hydrolized-Protein, Blood Pressure

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Published

2014-05-03

Issue

Vol. 2 No. 2 (2014)

Section

Articles

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